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KMID : 1141520230380020214
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Endocrinology and Metabolism
2023 Volume.38 No. 2 p.214 ~ p.222
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Brown Adipose Tissue: Activation and Metabolism in Humans
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Imane Hachemi
Mueez U-Din
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Abstract
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Brown adipose tissue (BAT) is a thermogenic organ contributing to non-shivering thermogenesis. BAT becomes active under coldstress via sympathetic nervous system activation. However, recent evidence has suggested that BAT may also be active at thermoneutrality and in a postprandial state. BAT has superior energy dissipation capacity compared to white adipose tissue (WAT) andmuscles. Thus, it has been proposed that the recruitment and activation of additional BAT may increase the overall energy-expendingcapacity in humans, potentially improving current whole-body weight management strategies. Nutrition plays a central role in obesity and weight management. Thus, this review discusses human studies describing BAT hyper-metabolism after dietary interventions. Nutritional agents that can potentially recruit brown adipocytes via the process of BAT-WAT transdifferentiation are also discussed.
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KEYWORD
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Brown adipose tissue, Diet, food, and nutrition, Medical imaging, Metabolism
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